Dear colleague,

We cordially invite you to the second ESPE Science Symposium which will take place on October 29th and 30th, 2021 and will be hosted at Radboud university medical center, Nijmegen, the Netherlands.

The ESPE science symposium aims to promote the development of an interactive network between clinicians and researchers, helping to reduce the gap between research and patient care. It will also provide the means to disseminate new scientific knowledge in the community of paediatric endocrinology. The symposium is organized every two years by a Local Organizing Committee (LOC) selected through an application process by the ESPE Science Committee.

Its focus will be ‘Congenital adrenal hyperplasia: from molecular medical research to clinical application’ and it will be supported by the Endo-ERN and the ESPE DSD Working Group.

The symposium will consist of interactive lectures by renowned scientists in the field with the aim of covering the main topics in CAH. We invited top clinical and basic researchers from all over the world with main research focus on CAH. There will also be discussions and networking time in the group.

We look forward to welcoming you in Nijmegen in 2021.

On behalf of the programme organizing committee,

Hedi L. Claahsen - van der Grinten, MD, PhD
Pediatric Endocrinologist, Associate Professor
Head of the Department of Pediatric Endocrinology
Chair Radboud DSD centre


Programme: Friday October 29th, 2021

09.00 Welcome
H. Claahsen-van der Grinten, the Netherlands


Session 1: General introduction and basic principles of CAH
Moderator: O. Hiort, Germany
09.05 - 09.25    Basic principles of steroid synthesis and adrenal enzymatic defects W. Miller, USA
09.25 - 09.40 The role of the backdoor pathway in CAH C. Flück, Switzerland
09.40 - 10.00 The role of steroid precursors in the pathophysiology of CAH H. Claahsen-van der Grinten, the Netherlands
10.00 - 10.30 Questions and discussion
10.30 - 11.00 Break

Session 2: Diagnostics and monitoring in CAH
Moderator: M.M.L. Stikkelbroeck, the Netherlands

11.00 - 11.20 The role of 11 ketosteroids in CAH S. Wudy, Germany
11.20 - 11.40 Urine steroid metabolomics as a diagnostic tool in CAH W. Arlt, United Kingdom
11.40 - 12.00 Neonatal screening in CAH P. Speiser, USA
12.00 - 12.20 Measurement of steroids in hair in CAH T. van Herwaarden, the Netherlands
12.20 - 12.40 Questions and case discussions
12.40 - 14.00 Lunch

Session 3: Treatment options in CAH
Moderator: C. Flück, Switzerland

14.00 - 14.30 Novel treatment strategies for patients with CAH R. Auchus, USA
14.30 - 14.50 Pro and con of prenatal DXM treatment A. Nordenström, Sweden
14.50 - 15.10 Standardizing sick day events and their management in CAH D. Merke, USA
15.10 - 15.30 Questions and case discussion
15.30 - 16.00 Break

Session 4: Basic research in CAH
Moderator: N. Reisch, Germany

16.00 - 16.30 The zebra fish as model for CAH research N. Krone, United Kingdom
16.30 - 16.40 Etiology of TART as an example for translational research P. Span, the Netherlands
16.40 - 17.10 What's new in enzymatic and gene therapy in CAH L. Guasti, United Kingdom
17.10 - 17.30 Models for novel therapeutic components A. Huebner, Germany
17.30 - 18.00 Discussion
18.30 Evening programme/dinner (included in registration fee)

Programme: Saturday October 30th, 2021


Session 5: Health related outcome in CAH
Moderator: M. Polak, France

09.00 - 09.20 Fertility issues in CAH N. Reisch, Germany
09.20 - 09.40 Cardio-metabolic risk in CAH P. Touraine, France
09.40 - 10.00 Psychological outcome in CAH H. Falhammar, Sweden
10.00 - 10.15 Questions and case discussion
10.15 - 10.45 Break

Session 6: Networking in CAH
Moderator: H. Claahsen-van der Grinten, the Netherlands

10.45 - 11.00 CAH in developing countries (Indonesia) A. Utari, Indonesia
11.00 - 11.30 How can we use the I - CAH registry for longstanding collaboration and research? F. Ahmed, Scotland
11.30 - 12.00 How to set up a longstanding CAH scientific network and general discussion

H. Claahsen-van der Grinten, the Netherlands
. Ahmed, Scotland

12.00 Closing remarks
H. Claahsen-van der Grinten, the Netherlands

Organizing committee



Hedi Claahsen - van der Grinten

Pediatric endocrinologist Radboudumc, the Netherlands

Teun van Herwaarden

Laboratory specialist Radboudumc, the Netherlands

Henri Timmers

Endocrinologist, chair of the Radboud Adrenal Centre, Radboudumc, the Netherlands

Nicole Reisch

Endocrinologist, chair MTG adrenals ENDO ERN, Munich, Germany

Olaf Hiort

Pediatric endocrinologist, chair MTG sex development and maturation, ENDO ERN, Lübeck, Germany

Christa Flück

Pediatric endocrinologist, chair ESPE DSD working group Bern, Switzerland

Agustini Utari

Pediatric endocrinologist, Indonesian Society of pediatric endocrinology Semarang, Indonesia

Faisal Ahmed

Pediatric endocrinologist, coordinator I CAH registry, chair ESPE science committee, Glasgow, Scotland

Michel Polak

Pediatric endocrinologist, member I DSD scientific panel, Paris, France

Amanda Helm

ESPE corporate relations manager, United Kingdom

Martin Wabitsch

Pediatric endocrinologist, ESPE science committee, Germany


The ESPE scientific symposium 2021 will be held in the Radboud university medical center, Nijmegen, the Netherlands. It is perfectly located close to the city center and easily accessible by car and public transport.


Radboudumc, main entrance

Geert Grooteplein Zuid 10

6525 GA Nijmegen

the Netherlands


Radboud university medical center specializes in patient care, scientific research, teaching and training in Nijmegen. Our mission is to have a significant impact on health care. We aim to be pioneers in shaping the health care of the future. We do this in a person-centered and innovative way and in close collaboration with our network. Around 10,000 staff and 3,000 students are committed and ambitious, helping to shape the future of healthcare and medical science.

Accommodation and Travel

There are several airports close to Nijmegen: Amsterdam Airport Schiphol: The largest airport in the Netherlands – Schiphol is approximately 90 minutes away and offers a direct train connection to Nijmegen (Schiphol - Nijmegen).

Weeze Airport: The closest airport to Nijmegen is in the German town of Weeze and approximately 40 minutes away from the city center. There are direct buses from Weeze Airport to Nijmegen Central station.

There are several hotels located nearby Radboud university medical center. Hotel suggestion: Mercure Hotel Nijmegen Centre, Van der Valk Hotel Nijmegen-Lent.


This symposium is limited to 100 attendees including faculty. Delegates may come from any professional clinical and scientific discipline which is related directly or indirectly to the topic. The congress fee is € 80 per attendee, including dinner on the first night.
Accommodation is not included in this fee.

Click on this link to register. You will be redirected to the site of the event management bureau:, they take care of the registration.

This symposium is organized by bureau-prevents.

Application free young investigator grant

ESPE offers 25 free registration spaces for young clinicians and scientists in training. We define this group as those who are less than 8 years (full-time equivalent) since completion of doctorate training. Participants who would like to receive one of these free places are required to apply.

The application should be submitted before the deadline and should include the following information:

  • Letter of support.
  • CV.
  • Publication list as first author.


Participants who would like to receive one of these free places are required to apply by completing this application form
and mail it to:


The application criteria are as follows:

  • Experience in paediatrics.
  • Special training in (paediatric) endocrinology.
  • A proven interest in paediatric endocrinology.
  • Knowledge of the English language.


Deadline for application June 1st, 2021.

The symposium is also open to other interested delegates with a congress fee of 80 euro to attend. Click HERE.


A certificate of attendance and CME credits will be provided.
(accreditation by the European Accreditation Council for Continuing Medical Education (EACCME®) with European CME credits)
Accreditation of this course by the Dutch Society of Internal Medicine and Pediatrics is requested.


Sponsored by

Congenital Adrenal Hyperplasia: From Molecular Research to Clinical Application has been endorsed by the European Society of Endocrinology who has also provided financial support through an ESE Small Meeting Grant.


Symposium Office:
P.O. Box 73
3480 DB Harmelen, the Netherlands



Hedi L. Claahsen - van der Grinten, MD, PhD
Pediatric Endocrinologist, Associate Professor
Head of the Department of Pediatric
Chair Radboud DSD centre
HCP representative ENDO ERN


More information





Registration is accepted according to the ‘first come, first served’ principle. Participation is only possible for the entire week.

For endocrinologists € 1250 and fellows in training € 995. This includes hotel room and meals.

For those who do not want to stay overnight registration fees are € 750 and € 550 for endocrinologists and fellows in training, respectively.

You will be redirected via this link to the site of, they take care of the registration.

This symposium is organized by bureau-prevents.